Did I say "remove"? No. I said focus on other things. A Dragonlance game that takes place in Krynn but does not focus on the War of the Lance (while it still goes on in the background) is still a Dragonlance game. Same way a Ravnica game that takes place in Ravnica but is not specifically about the Guilds is still a game in the Ravnica setting.That's like claiming that chocolate chip cookies without chocolate chips are still chocolate chip cookies. Or that replacing the chocolate chips with ground beef means they're still chocolate chip cookies.
Specific settings have specific details you can't remove without removing that which makes them that setting.
There's a reason the term "In Name Only" exists.
Maybe you can't conceive of a way to do it... but that's on you.