Lots of house rules, XP for playing your character with gusto and style, bonuses for acting "in character", hordes of variant monsters, lopping off of The Planes, homebrew setting, way, WAY stripped down combat, no use of minis, entire evenings where not a single die is rolled...
...don't know if we count as "fast 'n' loose" by your definition or not, because we do use the rules, so I voted one up from there, but for us the rules are there to put a generalized framework around the game, rather than to restrict options available.