Most classes would be fine with reduced cantrips. It would play a little like 3e where low level wizards use crossbows. You might consider giving full-caster classes a single ASL for STR or DEX, letting clerics wade into combat a little more and rely less on sacred flame, and wizards could use crossbows, thrown daggers and darts more effectively. Additionally you might need to change some domain/wizard specialization abilities. Change all instances of domains with Potent Spellcasting to Divine Strike, and give Evokers a similar ability called Elemental Strike to replace Potent Cantrip.