ST: The Next, Next Generation!
It's been SEVENTEEN YEARS since TNG ended. By the time this comes on (if it does), it will be nineteen years between the series. The same time gap between TNG and TOS, as it so happens.
We don't need some damn ST:Academy or ST:Voyager or ST

S9. We need another Enterprise, another Captain -- another main continuity line in the Federation. Stop trying to reinvent the damned wheel. The original concept was always the best.
It's time for the Enterprise F. No god damned Suliban. We need Klingons, Cardassians, Romulans (some doubtless survived) and the Borg. Add a new enemy in as needed but don't go ALL IN on some new villainous race until it is apparent that viewers like them. Play it a little cautiously in that regard. You'd think the Kazon would have taught them this lesson -- but Enterprise and the lame Suliban doubled down on that bravado -- unwisely.
And keep Vulcan destroyed. Roll with it and use that to explain why to accept (or ignore) any particular aspect of Trek canon they find to be inconvenient on a go-forward basis. The Vulcans would have retrenched and done their damndest to breed like rabbits in the intervening centuries. They are nothing if not practical.
Along with the Borg, the Klingons remain the greatest villains in the history of Star Trek. Making them all nice-nice was ultimately a mistake.
I don't mind bad guy Ferengi, but it is not possible to make them the central villains of the series -- anymore than it was possible in TNG. They SUCKED in the initial Farpoint. The Ferengi only got interesting later in the series and on DS9 when they were, well, comic relief.
The Borg are VERY scary; Klingons are scary; Romulans are scary. Cardassians could be very vile (
there are FOUR lights!); The Dominion could ROCK when it needed to... but Ferengi?
Fun characters from time to time, but not villainous enough. You just can't take them seriously.
While I agree that B&B need to go away and STAY away -- I'd be happy with Ronald D Moore at the helm. Not unrelentingly DARK R.D. Moore - but a little grunge amidst all that Humanism and boundless optimism would be just fine with me. RD Moore's take on the Klingons and their civil war was the best thing about the show, save for
Best of Both Worlds.
Do away with LCARS tech design motif, too. TN, NG would need a new look. Set it in the 25th Century. Double down on TNG and go with it.
Risky but possible: The Borg Queen showed Data how to graft human skin on to his structure. I thought they were going to go with this after First Contact to explain Spiner's obvious aging, but for some odd reason -- they chose not to go down that path. They could to this to Data and have an older Brent Spiner playing an older Data who ... ages.. in the series... but who is alive in the 25th Century. It's not as if his career is jumping; they can afford him easily. So they could have a version of Data on the show, as a regular or recurring cast member if they needed him.
Security Officer? I want to see a bad-ass Angosian Subidar in that role! (a la Roga Danar from
The Hunted).