I don't think it'd be a problem to mark stuff as open. Either you go with an "easily accessible" database of the stuff you want open, or you just jam it in where normal copyright leagalese is jammed in with the end credits.
As a double-plus bonus, that means that mods and homebrews of any Pathfinder videogame might be pretty popular.
Now, it would be impossible to do a GSL videogame, I think. But the OGL doesn't seem to prohibit it, and there's no d20 liscencing involved (which was the slightly more restrictive agreement with the decency clause and such).
That would make me dork out on Golarion more than anything else, and I think something like that has the chance to bring a HUGE audience to Pathfinder, even if only a small fraction of the videogame players bother with the pen-and-paper game.
I mean, it could end up like most D&D games and be a muddy mess, but at the very least, it could end up like KOTOR or some of the good Bioware D&D games (Baldur's Gate, etc.).