Jack Simth said:He permanently loses all spellcasting abilities.
What that MEANS is up to DM interpertation - some would say he can simply never take levels in any spellcasting class. Some would say he can't use scrolls/wands/staves even by UMD anymore. Others might say he can't make use of ANY magic item (except the cursed variety). Don't know of anything particularly RAW based.
Corsair said:From the will save? Nothing, assuming he doesn't normally have spellcasting abilities. (Though the question as to whether he can multiclass into a spellcasting class later is up for debate)
If I were the rogue, I'd worry more about the percentile dice.
"Note: Destroying artifacts is a dangerous business, and it is 95% likely to attract the attention of some powerful being who has an interest in or connection with the device."
Nightfall said:Actually I would make it that NO magic works on him, he can't heal normally, and he's forever cursed.
Hey artifacts man, disjoining them is tricky. Just ask Frazzy.