This statement caught my eye, and I thought it was worth a thread of its own, rather than derailing the original one:
I’ve never run more than a single campaign at one time. For those of you that do, how do you handle this? Multiple campaigns set in the same world? Possibly even coexisting and with the potential for the campaigns to influence each other? Or going with completely different genres to keep things straight in your head?
Tell me about it!
I've been involved in both.
As a player, I have been involved in parallel campaigns run by the same GM; the two groups were in the same game world but working toward competing goals. One time, this was in a face-to-face game of D&D 3rd Edition; one time was an online Greyhawk campaign that used GURPS 4th Edition rules.
As a GM, I have run different games (sometimes in entirely different systems) for different groups on different days of the week. This was usually the case when I was trying to both learn and run a new system and wanted to start with a subset my usual group. If things went well, it was easier to teach the rest of the group when a few other people had at least the basic ideas of the system down. I did this when transitioning from D&D 3E to D&D 4E; when first learning GURPS; and when first learning Edge of the Empire.
During early D&D 4E, there was a group with whom I played who had multiple games going at the same time because different people wanted to try GMing. It was mostly the same group but with one or two changes in personnel because of work schedules. There were games on Tuesdays, Saturdays, and Sundays. At the time, my own schedule worked out that I was available for all of them, so I was.
Currently, I have so much Dungeon Crawl Classics material, that I'm considering multiple groups so that I actually get to use some of the stuff that I've bought. I haven't yet decided if the groups will be taking place in the same game world or not.
*Edited to touch up some spelling