Pretty much as soon as I saw the first blurb about the series, I was thinking about it...not as the focus, but as a major feature of the campaign. Damn good sci-fi in that one! It reminded me of some of Gaiman's or Barker's stuff.
Unfortunately, even though I have the campaign mapped out, I don't have any audience- too many of the guys in my group are strictly D&D players.
I
could work it into a traditional FRPG game, but I have no urge to do so.
I think the approach mapped out above would work.
Another way to do it would be similar to the way the miniseries itself worked out- have someone with the Key (or other Object, like the Ticket or the Eye) somehow interfere in something the PCs are involved with.
You could even start the campaign off as a strictly normal Modern campaign, with the PCs being private eyes, policemen, or whatever...then drop the wierdness on them.
Perhaps they get recruited by a Cabal, or perhaps they stay independent operators- effectively their own Cabal.
BTW, something like The Lost Room was done years ago as a syndicated TV show: Friday the 13th the Series. No connection to the movies, it was about this family that was trying to recover cursed items (created by one of their ancestors) and placing them in a special vault. They operated out of an antique store- where better to find info on and acquire old (cursed) items?
You might want to check it out as well.