Well, I'll admit I like involving gods, because the PCs in my run have a destiny. But anyway, they implicitly trusted a thoroughly amoral individual, and he hit them with waer from the river styx and then threw them through a killing portal, turning their remain into, as it became known, "Astral Chum". The entire party wiped out because they trusted one of the most well hidden, amoral, and mercenary "villains" in the game. So I dusted off my old books and had Anubis, now Guardian of the Dead Gods, resurrect their pulped bodies (still minus their memories thanks to the styxian water) and set to them a task. And thus the party became temporarily The Nameless Champions of the Guardian, and played through the old Planescape Dead Gods module and prevented Orcus' resurrection, at which point Anubis acquired the flower of memory from his former brother/cousin Set, and restored the heroes memories to them, and sent them back on their original heroic path.
It was a hoot! Considering the fun, I really should TPK them more often...chuckle