My most trivial house rule is: "Your character must be interesting."
This actually did not originate in a D&D game, although I have decided I probably ought to use it when I run D&D. It came from a Nobilis game I was trying to run in which character creation started with a personality and history before doing anything stat-related, and one person said, "I want to play a random college student who doesn't do anything meaningful, has no ambitions in life, and is not interesting in any fashion whatsoever. My character will only be interesting when he has powers."
Then when I created the rule, I received a lot of protests from my players that I was stifling their creative process by insisting that characters be interesting.
The game fell apart pretty fast after that.