Changeling - can't really judge. It isn't out, I've just read a bunch of previews... I like what I see so far, will pick up the game, but can't comment right now.
The mechanics of the new Mage are better, but the background is bland. I used Mage's frame and replaced the orders with Nephilim's Major and Minor Arcana. Little impact on the mechanics, great benefit on the background side of things.
Werewolf is more generic now than its oWoD version. It's a good game when you like dark yet heroic games with a touch of shamanism and lovecraftian weirdness for good measure.
Playing a WoD Mortals game can be great fun, but I don't especially feel like it's original. Chill, Call of Cthulhu/Delta Green, d20 Modern... there are many ways to do this. Is it the best option for a mortals' game? Depends on the type of game you want, I guess. Now, using WoD mechanics with Delta Green... that could be great!
Now, my real two favorites are Vampire and Promethean. They are very different games, though. For the social, political aspect of things, with schemes behind the schemes, treachery, twists and turns, urban chronicles, it's Vampire. For chronicles more centered around the PCs as a group, the notion of the PCs' evolution and possible redemption, a feel of alchemical quest to understand what it means to be human, it's Promethean. Both are outstanding games, for very different reasons.
Just for the sheer originality of the game concepts, if I had to choose between these two, I'd choose Promethean, I think.