I was running a Space Opera "one-off." At the end of the "blow up the space pirates" encounter, I felt that I needed to have a little fun, and take the Space Opera a lot less seriously. I put in everybody's favorite (what are those things called) robot: Marvin the Server.
He would constantly tell the PCs how dull life is for a robot with an I.Q. of 10,000 (his Int stat is 25, actually). Then one of the PCs ordered a Pan Galactic Gargle Blaster. You heard right, a Pan Galactic Gargle Blaster.
She drank it and yelled "WOW!" and was instantly inebriated.
We had a lot of fun not taking the game seriously!
I thought you might get a real kick out of that one, Gary.