A "The Legend of Vox Machina" boxed set, pushed by both Hasbro and Amazon, using many of the artists that worked on the animated series to make the art for the books. Should be more like a pathfinder boxed set with punch out cardboard pog minis, some generic battlemaps, and some cards for items, etc. It needs to be priced right. Has to be more than the current boxed sets to make it feel like a more hefty, everything you need to get started, game. But no so expensive that it would be passed over as too expensive for christmas/bday presents.
If the Amazon series takes off and if the boxed set has a lot of goodies besides some booklets and dice, I could take D&D even further into the main stream. Since the D&D movie is still a long way off, this would seem the best the best bet for a ubiquitous box set to be available in Target, Walmart, etc. (and of course on Amazon) by Christmas 2021.