I'd say the method of creation doesn't matter a lick,
@Argyle King.
If someone is born via invitrofertilization or we one day create an AI advanced enough to be a thinking being, they'll still be culpable for their actions so long as they're free willed and sapient. Cognizant of their actions and their consequences.
Like you'd never accuse a toddler of Murder for pulling the trigger of a gun they're playing with. Nor is it suicide if they accidentally shoot themself. It's just a tragic accident. That's still a human person who has killed someone, but there's no culpability 'cause they're completely incapable of making a moral decision. Practically any decision, really.
As to the Tolkienesque Orcs: They're sapient. They're also free-willed, as we see them disobey orders, kill each other for loot, and flee from a battle they've been ordered to. So declaring them all evil and that their entire race is itself evil -really- plays into racist tropes and ideologies.
In your D&D example you've just described a Murder. Someone killing another person for personal gain. It can never -be- justified to kill someone to enrich yourself. Now to kill someone because they're attacking you? Sure. To kill someone because they're an immediate danger to others? Sure. To kill someone who is an enemy of the realm while you serve the realm? People generally agree that's okay but it's dicey in my book.
Nature vs Nurture isn't something I've actually -ever- seen anyone want to explore in D&D. Some people obliquely reference it, typically when the party is about to adopt a Goblin or Kobold or something as a team-mascot and/or baby... But actually -exploring- it? It would take so much time and effort to compare and contrast and in the end it's all a foregone conclusion based on the story as written. Either the character's nature wins or their nurture wins not based on any exploration but entirely on DM Fiat.
With something like an angel it may seem egotistical to declare them unaligned... sure. I don't deny that. But it's not a real being. It's a fictional character we make up and it's goodness, evilness, or unalignedness is entirely up to us. There earnestly isn't a Cosmic Being involved that gets a higher say than we, the audience-participants.
I'm not sure I understand your final paragraph.