Hmm. My first thought is one that always starts a fight and I’m not up for that. Thinking further…
Dammit, my second thought is Pern, but no, too much trouble around that one too.
Okay, third thought is Strikeforce Morituri, and that one would work. It’s a few decades from now and aliens with superior force have been hammering Earth for four years. Now there’s a potentially war-changing process that gives people super-powers. It’s also guaranteed fatal within a year. The original series ran for 20 issues, and by its end all the first generation of Morituri were dead and nearly all of the second. A campaign could make use of the invaders’ morale-breaking schemes as potential developments, provide ways various powers could do the kinds of things done in the series, and set up developments of the second series as a smorgasbord of possibilities.
Jacqueline Carey’s Kushiel series has a wonderful setting and great stories…but sex is central and prominent, and I don’t see that going well except as an indy game that never reaches the sale heights of Monsterhearts or Bluebird’s Bride.
Hmm. Martha Wells’ Murderbot? It’s got a solid setting not too complicated to assimilate and the conceit of robots developing their own purposes would work great for play focusing mostly on a single PC.