D&D5e shouldn't make wealth more worthwhile.
The conscious design decision was made to limit characters to 3 attuned magic items, that only leaves a few non-attuned items as useful for characters. So beyond that and bags of holding with a few hundred potions in them, money on personal power can't really be spend. And while I like this less then in the flexibility it gave in 3e, it gives a very good lesson! Beyond a certain level, wealth is useless for personal power or personal health. A real world ace mercenary can only spend so much on equipment, a tech baron can't spend his money to become immortal. They do spend it on other stuff...
The same goes for PCs, what's your motivation for adventuring? Paying off debt is possible, but imho a very uninteresting motivation, almost a cop-out. The classic tropes include for fame AND fortune, to retire early and live a very comfortable long life. Others adventure for personal power, be that a powerful artifact or become a Lich, etc. None of those things are
just bought with personal wealth... Also keep in mind that there's an economy in place...
From our 5e campaign we found some very expensive stuff, and started buying oodles of potions, even in a big place like Neverwinter. Eventually stock will run dry, making new stuff will take time, there's a limited amount of people that can make it, and if there's more demand then supply, prices will go up. Other adventurers will NOT like that either!
Other things, buy a home and/or base, fill your library, buy transportation options, hire staff, etc. You can use money to get/maintain contacts. Pay taxes, pay your church, and if the dice are with you for a session, you need to gift a LOT to the goddess of luck! Just to sure...

If you're more socially inclined, do some good works, like building a school and running one for free, buying up the slums and lowering rent. Importing food cheaply, provide healthcare, upgrading the sewers and the aqueduct.
Also keep in mind that wealth can be stolen, unless your lugging your 100k gp in four bags of holding... I call that a moving target by the way...
As for comments about 'simcity' mode. General rp stuff can be done in game and absolutely depends on the players/dm. Most of the detail stuff can and should be done between games. We bought a home and paid people to renovate it to our specs, the home schematics were done outside of the game by the players with final DM approvement. This is not new, we did this in 2e, 3e, and now 5e for decades, including in other games...