It isn't "superhero fatigue" it is "MCU fatigue" -- that is, superhero movies that all feel the same. Some tone, same tropes, same beats. This extends beyond the MCU: the MCU-like DC movies have also exhausted folks.
Make good movies with super heroes in them. Do interesting things. Take chances. Both Loki S1 and Moon Knight S1 showed you can still tell interesting stories in the MCU. The Boys and GenV show that there are options beyond jokey PG drek.
And maybe it is time for the superheroes to be born in the cinema or on television again.