Hrm, I recall advancing one for my campaign, although it's considerably tougher than what you need, it might provide a guideline for what you can do. I tinkered with the monster after applying the template and didn't bother with the other spell-likes as they seemed to arcane for me, instead upping the mind thrust damage. I would suggest taking away the chad mod to con that I added to it, reducing its AC to somewhere around 24, reduce fast healing to around 5 or 10, dropping that turn resistance to +4 or 6, and dropping mind thrust to 6d10-ish for somewhere closer to what you're looking for.
The one I used:
Brain in a Jar, Evolved Undead (x10): CR 18ish; Tiny Undead; HD 9d12+72; hp 120; Init +7; Spd Fly 30 ft (good); AC 37 (+2 size, +7 Dex, +18 deflection); SA Mind thrust, picnics, rebuke undead 11/day (9th level cleric); SQ Blindsight 60’, darkvision 60’, DR 5/-, fast healing 30, madness, telepathy, undead traits, +14 turn resistance, undead traits; AL NE; SV Fort +3, Ref +10, Will +7; Str --, Dex 24, Con --, Int 16, Wis 12, Cha 26.
Skills and Feats: X; Ability Focus (Mind thrust), Dodge, Greater Ability Focus (Mind thrust), Iron Will.
Mind Thrust (Su), 9d10 damage, Will DC 27 negates
Spell-like Abilities: 3/day-Suggestion, Telekinesis, 1/day-Dominate Person (DC 17+spell level), Manifester level 14th.
Example of a tweaked critter:
Brain in a Jar, Evolved Undead (x?): CR 12ish; Tiny Undead; HD 9d12; hp 76; Init +7; Spd Fly 30 ft (good); AC 27 (+2 size, +7 Dex, +8 deflection); SA Mind thrust, picnics, rebuke undead 11/day (9th level cleric); SQ Blindsight 60’, darkvision 60’, DR 5/-, fast healing 5, madness, telepathy, undead traits, +6 turn resistance, undead traits; AL NE; SV Fort +3, Ref +10, Will +7; Str --, Dex 24, Con --, Int 16, Wis 12, Cha 26.
Skills and Feats: X; Ability Focus (Mind thrust), Dodge, Greater Ability Focus (Mind thrust), Iron Will.
Mind Thrust (Su), 6d10 damage, Will DC 24 negates
Spell-like Abilities: 3/day-Suggestion, Telekinesis, 1/day-Dominate Person (DC 18+spell level), Manifester level 14th.
I do have to second having some sort of tough minion type creature to go along with the brain, preferably something mindless/immune to crit hits and such like a construct or undead.