Parmandur
Book-Friend, he/him
Fair enough!
To me, D&D space pirates seems precisely the sort of thing that I would look to a 3PP for. But as you say maybe I'm too conservative in my thinking!
They've already published a book that has a very campy Mindflayer Space Pirate stuck miles underground. Weird and campy are part of the current house style (Flumphs, the continued emphasis placed on Modrons, Gith, etc.).
Weird fantasy is pretty in style right now. Their strategy with Settings now seems to be as themed booster packs for genres: what genres they see a market for, will likely get Setting support. Planescape, per WotC, is a very popular Setting for them, and has the advantage of being something that can slip into most standard campaigns.