Celebrim
Legend
One of the most difficult obstacles in a D&D type campaign is for a DM to be able to develop a pandemic that poses a threat to the characters and such. How do you counter the old standby Cure Disease spell so you can have a plague ravage the land and have the PCs be a part of it?
There are many plagues and maladies on my world of a magical nature, bolstered by the powers of darkness, which resist easy cures. Generally speaking, they require caster level checks to remove.
The seven plagues and the disease they are loosely based on are:
The Black Death (Plague): Caster level check 15+
The White Death (Tuberculosis): Caster level check 12+
The Yellow Death (Yellow Fever): Caster level check 13+
The Purple Death (Cholera): Caster level check 16+
The Red Death (Ebola): Caster level check 18+
The Green Death (Influenza): Caster level check 11+
The Spotted Death (Small Pox): Caster level check 14+
Generally speaking, these diseases are virulent enough that they quickly overwhelm the combined priesthoods ability to cope. A city might be able to cure 2 or 3 cases per 1000 people per day. If scores or hundreds of people are contracting the disease daily, clerical resources simply won't be able to keep up.
Each outbreak of these is also usually accompanied by at least one Greater Disease Spirit, which generally has to be dealt with or appeased to end the outbreak. Remember that we aren't dealing with a culture that lacks a germ theory of disease; we are potentially dealing with a world where germs aren't the cause of disease but rather malevolent spirits are the primary vectors.
It's also worth noting that Cure Disease confers absolutely no resistance to future exposure to the disease.
Some diseases, like Lycantropy, require both caster level checks and the outlay of certain rare ingredients to cure. It's generally far safer to destroy lycanthropes than to try to cure them. It's often hard enough to contain the disease by curing the ones that slew the last batch without trying to redeem the full lycanthropes.