Yes. Back in the late 70's my dad brought home the basic boxed set and he DM'd for me and my brother. It didn't last too long, but it got me hooked on the game.
My wife & I played loads of Baldur's Gate, Icewind Dale, & Neverwinter Nights back in the 90's and early 2000's.
In January 2015, my family was at our local bookstore. My kids were looking to spend some of their xmas $. I heard my wife and daughter call me over, holding the 5E starter set. "Wouldn't it be fun to play as a family?" Yep, it has been fun. Our daughter just left for University, and the other day when she called home she said "I've met so many people that play D&D! I'll have to bring my stuff next time I'm home!"
My wife wants to take the reigns and DM for me and my son. She thinks I will mesh well with our son's adventuresome, chaotic, imaginative play style. Big sister's cautious, "let's think things through" style tended the clash with his.