Actually, the more I think about it, the more a modified Creation might well be my 4e game world.
Roughly, I'm thinking Human scattered all over, Elves to the far East, Halflings in the Threshold, Eladrin to the far West (cause I like them with pear white island cities), Dwarfs to the North, Dragonborn to the South and a corrupt regime of Tieflings ruling the Blessed Isle.
Might be too symmetrical, but I'm also contemplating an old school sort of video game craziness like in the thread I posted earlier.