I would easily give the show an arbitrary 8 out of 10. The pilot was solid...it introduced the characters without a deluge of exposition, put forth a lot of concepts, and delivered a solid, entertaining space opera. Lots of character hooks and hints dropped, and plenty of potential for the characters to grow. Nice to see Ron Glass' Sheperd character, for example...I suspect the priest has quite a checkered past, as we'll discover.
Did we actually establish that Irana was a prostitute? I know she's referred to as a 'Companion', and that apparently it's a position...but did they establish what she does? I didn't quite catch all of the captain and her dialogue early on. She's obviously not poor, having her own shuttlecraft.
Only time will tell how good the execution is, but so far I think it's off to a solid start.
As for John Doe, I took a pass. I just saw the Bourne Identity.

Seriously, I just don't see them being able to maintain such a concept for too long, and frankly the 'I know everything
except who I AM! (startled Gasp!)' things has been done a few too many times for my taste. It might be a good show...but I just can't generate any enthusiasm for it. If I hear enough good things about it, maybe I'll check it out.