I would count the mtg books as new settings, and Wildemount too.
I don't. The MTG books are from MYG settings that WOTC already owned. Outside of Strixhaven, it was just converting something they already owned. So it's a new conversion but not a new creation.
And Wildemount is just an official licensing of a celebrity's creation.
WOTC hasn't created a wholely new setting for D&D in over 20 years.