TwoSix
Magic 8-ball says "Not Encouraging"
Definitely.Sure, sure.
I'm mostly just thinking in terms of the magic system. Now that you mention it, LotFP also added a dash of additional randomness to that, just through the Summon spell, which both made summoning unpredictable and dangerous, but also had a bunch of absolutely bonkers miscast possibilities, in keeping with the desired cosmic horror theme. LotFP did have a number of other mechanical tweaks and innovations (like slot based encumbrance, as I recall). Though the main one in magic was removing spells which made magic flashy or allowed it to easily circumvent problems like curses, death, or detecting evil people easily.
I think it was pretty obvious to early experimenters that if you wanted to change the stories the games could tell, the first and easiest place to innovate was the magic system.