Blackshirt5
Not to mention the fact that as far as is known, the Iroquois never took to using primitive germ warfare as the colonists did, in the form of smallpox victims blankets being handed out to the indians.
Funny thing, the first Smallpox blankets were handed out by humanitarian groups who wanted to help keep Indians warm. The dead didn't need 'em anymore, so they got laundered and given away.
Unfortunately, Smallpox isn't so easily gotten rid of, and what you might expect happened. People put two and two together, and started handing out Smallpox blankets deliberately.
Back to the Setting
Since some folks will want to play European style knights and wizards, will there be any sort of contact with a European type setting? Or will there be guidelines regarding difficult (as opposed to nearly impossible) travel between the two lands? Since long term contact is likely to produce substantial changes, I recommend it be set up so that play commences during early contact days. For that matter, it would probably be best if you did it much as CWD did
Nyambe. A fictional America and a fictional Europe.
The Old world is experiencing something of a population explosion, with the result that the old fishing grounds are getting fished out in order to feed people. So Old World fishermen are going further and further afield to find fish.
It's been twenty years since the first European fishing villages were established on the coast of the New World. Some fishermen have brought their families over, others have married into the local tribes. Some of the natives have married into fishermen families, and they and others have taken up the fisherman's life.
At the same time some of the Old World nations have sent people to keep an eye on
their subjects (What Medieval despot in his right mind is going to give up tax revenue if he can avoid it?

), while the Iroquois analog has taken notice of these new people and decided they too should be invited to join the Five Lodges. (Whether they want to or not. The Huron were originally invited to join the Iroquios about the time the French came to North America. They refused. The Iroquois set about destroying the Huron Nation.)
Then you have the non-humans -both Old World and New World- who are learning about their counterparts across the sea.
(You know, if I keep writing at this pace I may have to ask for co-author status.

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