I like the idea of sourcebooks to campaigns (I can picture adventures set on the high seas having nautical options, or those dealing with undead having ghostbusting goodness), but I'm not crazy about everything being tied to the Realms. I get why--it's popular, its safe, and easily ties to the Neverwinter game--I just hope they branch out after a while.
I would love to see one story arc per year be the generic fantasy/Realms (perhaps with guidelines for using it in Greyhawk or some such), but the other being more themed to a specific setting with a completely different feel--like Eberron, Ravenloft, or Dark Sun. I get that these settings are more niche, but if every other campaign is the standard fare they have a bit more freedom to experiment.
I also hope we see some standalone adventures that aren't big campaigns.