I wouldn't consider myself a huge fan of FR, I've had much more experience with it through video/computer games and board games than in actual table play, but I've read a decent chunk of the modules (especially the newer ones) and I've got a good idea of the cursory lore down. I've certainly heard of Waterdeep, Baldur's Gate, Neverwinter, Silverymoon, Calimport, Shadowdale, Phandalin (which is honestly easily in the top 3 of FR municipalities I hear conversations about these days), Menzoblahblah (which I've definitely heard about but don't care enough to learn how to spell properly), and many of the others you've named. This has, however, been the first time I've heard of Skuld, but then I almost entirely skipped 4e so that may be on me.