I find the slot based inventory in the 5e darker dungeons suppliment (link) to work very well, the biggest problem in my experience is the same as any other house rule... Namely "OMG!!! DDB doesn't support it or any of WotC's own variant rules and muh subscription must limit your game so I'll fight you tooth & nail at every chance I get".
shrug. D&DB doesn't actually support any encumbrance rules, does it? It puts up some text when you are over your limit, but it doesn't change your speed for that. Nor does D&DB support use of encumbrance-reducing items (like a Bag Of Holding).
So, if you are tracking encumbrance, you are very likely having to do so outside the app anyway, so D&DB arguments are null and void.