Never a full campaign, but in a previous D&D 3.5 campaign I managed to get the PCs, who had ended up on a spelljamming vessel due to falling prey to a teleport trap while seeking out a notorious pirate's treasure hoard, spending several adventures as "slave-pirates of the neogi" when a neogi deathspider vessel overtook their small spelljammer and forced them to become part of their disposable crew. They had a good time escaping the neogi, wreaking some vengeance against them, and then high-tailing it back home in a new spelljamming vessel they stole (a damselfly, if I recall correctly).
Johnathan