It really depends on the type of campaign I want to run. Under normal adventuring circumstances, the standard short & long rests work well enough, although I've added a medium rest houserule. If I want to do a campaign based more on exploring or traveling, I use gritty realism for short rests and 3 days of downtime for long rests (7 days is too long for me). I might consider epic heroism if I was doing a campaign based almost entirely on combat, since rests just break up the action.
Medium Rest Houserule
A Long Rest has to take place in a Sanctuary, which is basically a relatively safe place you could spend downtime, and recovers all HD instead of half. While generally this means in town, it could include a druid's grove or other wilderness environment that's sufficiently protected (entirely GM's discretion). The purpose behind this is to prevent fully recovering mid-adventure, which is replaced by a medium rest.
A Medium Rest replaces the existing long rest when outside of a Sanctuary. You recover half your max HP, half your HD, and half your once/long rest abilities (minimum 1). Abilities that you can use a number of times per long rest recover half their number of uses, and you recover 1 spell slot per level, up to level 5 spell slots.
Medium Rest Houserule
A Long Rest has to take place in a Sanctuary, which is basically a relatively safe place you could spend downtime, and recovers all HD instead of half. While generally this means in town, it could include a druid's grove or other wilderness environment that's sufficiently protected (entirely GM's discretion). The purpose behind this is to prevent fully recovering mid-adventure, which is replaced by a medium rest.
A Medium Rest replaces the existing long rest when outside of a Sanctuary. You recover half your max HP, half your HD, and half your once/long rest abilities (minimum 1). Abilities that you can use a number of times per long rest recover half their number of uses, and you recover 1 spell slot per level, up to level 5 spell slots.