All this ^^^.As mentioned, it depends on the system you use.
In 5E you could get through one combat.
In Call of Cthulhu that would be about half of a standard one-shot scenario.
In a rules light game you could storm the beach at Normandy, assassinate Franz Ferdinand, start a revolution, colonize a planet, defend an outpost against alien invasion, summon the hordes of hell, or just about anything you can imagine.
Drop the grid, and maybe combat altogether. Use a system that invites interpretation and quick resolution. Play fast and loose with the rules. Run something you know really well. For the love of all that is holy, don't let them start conversations with shop keepers.
Do all that and you can accomplish a lot in 2 hours.