If you take the world of the Dark Crystal, for example . . . not a human in sight! Not even any Tolkienesque elves or dwarves! The gelflings and podlings aren't too far away that though, and certainly are the point-of-view characters for the audience.
Running a D&D game where humans aren't any more common than a myriad of other races, perhaps even less so, sounds like it could be a lot of fun! Count me in as pro-cantina!
True story: My friend and I were at a party in California (many years ago). In walked a girl and we could not stop staring. My wife asked if I knew her. I said yes, but it was impossible. My friend just stared and stared and stared, and in between stares, he would look at me with huge eyes that asked: Is that possible?
I swear to you. 100% truth. She looked identical (no surgeries) to the gelfling girl (Kira?). Identical. My wife thought I was staring because it looked like she had a slight defect. But, I was, in a weird way, star struck. It was so profound, that we eventually went and talked to her, and asked for her picture (after showing her a picture of the character).
So if you are in Cali, be on the lookout for a gelfling. They exist, and it is fascinating.