Title? I don't need no stinkin' title.
Same here. For my home-brew setting (that I won't shut up about, apparently), I'm taking far more inspiration from the civilizations of the Bronze and early Iron ages from around the globe (with a few, like my vaguely Incan-esque mountain-dwelling elves, taking inspiration from civilizations from later points in history and from fiction) and trying to avoid a one-to-one adaptation (those Incan elves will take inspiration from elsewhere—like the Air Tribe Avatar, the last Airbender, also). I like Middle Earth, I like Greyhawk, but I don't want to create a setting that emulates either.
I'm so sorry. IMO, you should go ahead and take the plunge in trying something different that you like. Your players may be more amenable to and easier to roll with it than you think. Heck, if it fails spectacularly, you always have the tried and true to fall back on.
Yeah, I'm thinking after the current campaign is done, proposing a mini-campaign. Maybe one where people keep bouncing from genre to genre and only have a vague memory of who they are?
I'd run it by my players first of course.