Would you like to play Synibarr?
I would not play Synibarr, Clay.
I would not, could not play Synibarr, no way!
Would you, could you play it in a house?
ok, you get the idea.
Yea, I think system matters for me. Probably creation rules, house rules, etc, matter less, though they can be obnoxious if they aren't well thought-through.
I haven't come across any White Wolf game I like. I have no desire to play "lethal" or "one-shot" style games like CoC. The point of Paranoia is kind of lost on me. Earlier editions of D&D kind of grate on my nerves, since I find them so restrictive.