Had our first game last week.
Went well, DR changes were the big thing we were exposed to, as well as character updates. The enchantress, who got screwed the most by the rule changes - SF, GSF, double extended buffs, haste, conjuration as prohibited school so poof goes Teleport, and a toad familiar (who is currently embedded in her skull - long story) - she was the biggest fan of the change. The Bard, who only lost the heinous damage he was doing as an archer with GMW and otherwise gained across the board, was the most resistant. Our cleric is the most unfamiliar with the d20 rules in general, so she was concerned about having to learn all new stuff. Fortunately her changes were light. The other two have custom prestige classes that didn't change, but they both were using my houseruled Ranger class, which was amazingly similar to the new Ranger class, so only minor tweaks there.
The new DR rocks. The only downside is that the party is out in the desert hunting demons and diabolists, so we had to retcon some shopping for cold iron weapons.