Mutants and Masterminds all the way. Possibly BESM D20 too (mostly because of the GM). I got M&M just because I could, pretty much, and it turns out that I'm really enjoying playing with it (or I would, if I did't sound like I was going through puberty again, but that's a different story...). I can make any character I want to in under 30 minutes, I've had 3 campaigns with it (two that failed to start, one that seems to be going strong, even though the GM doesn't have much confidence yet, and he's faced with me, the Min/Maxer (who isn't proficient enough with the rules yet to be a threat), and the Munchkin, but anyways...). Definitely the most-used book outside of the core D&D books I have.
Also, the GM for the M&M game just looked through the rules yesterday, and is quite impressed by how easy it is to make a character on the fly - just take a power, add some abilities (or nab them from the front of the book - I need to get the Crooks book so he has more to nab from...), and instant character, ready to go.
So, yeah. Mutants and Masterminds it is.