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D&D and the rising pandemic


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FitzTheRuke

Legend
Moderna already has their next R&D project: make the protection stick long-term.

And they do owe their lab teams some hefty bonuses. Imho.

Agreed. Like I said, I have no problem with anyone getting paid. I just don't like it when ALL the money gets taken away by some rich guy at the top. If the massive profits go back into research (with some bonusses all around for a job well done) then the system is working like it ought to. They can make profits again the next time they come up with something worthwhile - I have no issue with that!
 

Umbran

Mod Squad
Staff member
Pfizer, though, wasn't called out.

The measure that makes sense is probably not the absolute number of doses, but the fraction of doses manufactured that have gone to poorer countries.

Also, we would want to look at the manufacturing cost of each. If Pfizer does it cheaper, they can cut the price and still realize the same profits.

Because, let us not kid ourselves that Pfizer isn't making a mint on this - they took in $3 billion in covid vaccine revenue in the first three months of 2021, and $9 billion in vaccine sales in the second quarter. Which suggests to me that Pfizer is selling a lot more than Moderna, so they darned well ought to be making more available to poor countries than Moderna.
 

Zardnaar

Legend
Big vaccine push on. Nationwide 82/58% 1st/2nd dose vaccine and there's a mass vax event for Saturday.

Aucklands hit 87% single dose where the outbreak mostly is. 63% double dosed. 43 cases today.

Boring stuff.

If you're super keen the first 5 minutes or so is the important part.
 

Dannyalcatraz

Schmoderator
Staff member
LOTS of interesting things on the horizon!

Several new therapeutics on the horizon. In addition to Merck’s pill, AstraZeneca’s new monoclonal antibody therapy promises up to a whole year of protection Neither, researchers point out, are a substitute for vaccination, because they’re not preventative.

 

Dannyalcatraz

Schmoderator
Staff member
This article on Merck’s new antiviral pill has a nice pros & cons section at the end:

Looks like the biggest stumbling blocks are its price ($700) and a somewhat narrow therapeutic window- it has to be administered before severe symptoms manifest.

This small window of opportunity means that for it to be most effective, we need accurate, rapid tests for diagnosing COVID, and an acceptance of contact tracing. I suspect solutions to the former will come in the relatively near future, while the latter will be more problematic. Still, one thing that might sway contact tracing skeptics is that some researchers believe that administering the pill to asymptomatic people who have been in contact with someone diagnosed with COVID may be functionally similar to getting vaccinated.
 

Eltab

Lord of the Hidden Layer
This small window of opportunity means that for it to be most effective, we need accurate, rapid tests for diagnosing COVID, and an acceptance of contact tracing. I suspect solutions to the former will come in the relatively near future, while the latter will be more problematic. Still, one thing that might sway contact tracing skeptics is that some researchers believe that administering the pill to asymptomatic people who have been in contact with someone diagnosed with COVID may be functionally similar to getting vaccinated.
Fully agree about the first point. Something that tells you "You do / don't have COVID" while being as easy inexpensive and reliable as a pregnancy test, would go a long way toward controlling the germ - and address the 'Expert's blessing required' bottleneck problem.

A medicine pack to take when your friends at work have caught COVID, if presented like a "COVID-formulated One-A-Day" (or Geritol or Flintstones based on age), would address one of the big gaps in our response to date: something that can be easily worked into daily routine.

I saw in a grocery a 'Healthy You' liquid vitamin that was mostly covered with a standard label "not endorsed by the FDA to treat any disease" but featured Zinc and Vitamin D as chief ingredients ... so we know what the intended purpose of that product really is.
 

Dannyalcatraz

Schmoderator
Staff member
Fully agree about the first point. Something that tells you "You do / don't have COVID" while being as easy inexpensive and reliable as a pregnancy test, would go a long way toward controlling the germ - and address the 'Expert's blessing required' bottleneck problem.

A medicine pack to take when your friends at work have caught COVID, if presented like a "COVID-formulated One-A-Day" (or Geritol or Flintstones based on age), would address one of the big gaps in our response to date: something that can be easily worked into daily routine.

I saw in a grocery a 'Healthy You' liquid vitamin that was mostly covered with a standard label "not endorsed by the FDA to treat any disease" but featured Zinc and Vitamin D as chief ingredients ... so we know what the intended purpose of that product really is.
I’m not sure it will be OTC any time soon. You’d probably need to see a doctor first, for the near future. And that means some kind of contact tracing.

Eventually, though, if/when it becomes available OTC, you might be able to get it at an institution’s on-site dispensary out of their first-aid kit.
 

Umbran

Mod Squad
Staff member
Fully agree about the first point. Something that tells you "You do / don't have COVID" while being as easy inexpensive and reliable as a pregnancy test, would go a long way toward controlling the germ - and address the 'Expert's blessing required' bottleneck problem.

I'm sorry, folks, but at $700, your insurance company is NOT going to cover it based on a self-test. The self-test, at best, tells you you need to see a physician immediately if you want this drug.
 



Mirtek

Hero
I don't believe there's been any solid testing on the efficacy of cross-brand boosters at this point. That doesn't mean it won't work, but there's no study behind it yet.
There must be some. At least the German RKI, and I also believe the EU EMA, changed the recommendation to follow a first shot of AZ with a second shot of Pfizer or Moderna. It's seen has being more effective. They changed the official recommendation in July or August already
 

Umbran

Mod Squad
Staff member
There must be some.

All the data I have read about has been small scale, preliminary stuff.

Do remember, we are only now getting to a time where folks would be considering boosters, much less for there to be valid large-scale studies of cross-brand booster efficacy.

At least the German RKI, and I also believe the EU EMA, changed the recommendation to follow a first shot of AZ with a second shot of Pfizer or Moderna. It's seen has being more effective. They changed the official recommendation in July or August already

So, I'd need a reference to know - but that sounds like a change to the possible initial vaccine protocol, not to boosters. Different use cases, need to be studied differently.
 

Dannyalcatraz

Schmoderator
Staff member
Canada has apparently been doing mix & match vaccinations for a month or so, and their numbers are still good. Based on the Canadian “experiment”, other countries are considering that going forward.
 

FitzTheRuke

Legend
Canada has apparently been doing mix & match vaccinations for a month or so, and their numbers are still good. Based on the Canadian “experiment”, other countries are considering that going forward.
We've been doing it for a lot longer than a month. We started it months ago in the summer. I nearly had a mix myself but the week I went for my 2nd they got more Moderna so I wound up with two of that. My whole family had 2 of Pfizer. I am the odd one out.
 

Zardnaar

Legend
The had a super vaccine weekend here and set a new record of 120k vaccines in a single day (population. 5 million).

Daily cases slowly increasing 60 cases today. Aucklands spent around 2 months in lockdown.

No Covid locally but waiting for that penny to drop in next few weeks.

All immediate friends and family now double shot. 82.3% single shot iirc 63.6 both shots.

They made it a large social event with food, pasifika entertainment, food and grocery give aways etc.
 

Hussar

Legend
Yay for my city. Population a tad under a million and no new cases for three days. Total cases since the start of things, 10000 (ish). Not too bad.

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Ryujin

Hero
Canada has apparently been doing mix & match vaccinations for a month or so, and their numbers are still good. Based on the Canadian “experiment”, other countries are considering that going forward.
It seems to have been more of an issue with availability of certain vaccines, than any sort of planned "experiment." The concern was to make sure that as many people as possible got something. There was also more than a little concern that one of the vaccines that we have been given was not recognized by the US and, therefore, would not permit people who were "fully vaccinated" with that vaccine to travel to the US.
 
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Dannyalcatraz

Schmoderator
Staff member
It seems to have been more of an issue with availability of certain vaccines, than any sort of planned "experiment." The concern was to make sure that as many people as possible got something. There was also more than a little concern that one of the vaccines that we have been given was not recognized by the US and, therefore, would not permit people who were "fully vaccinated" with that vaccines to travel to the US.
Hence the quotation marks.

But fortunately, pragmatism hasn’t seemed to hurt the actual patients!
 


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