I'd like to see a Dragonlance reboot, set in chronicles. There's so much fluff that turns crunchy. (Does that make sense?)
So many awesome concepts:
The re-emergence of clerical/divine power.
Low level Wizards having to pass a potentially deadly initiation into an alignment based order.
Towers of Sorcery factions having a rivalry/cooperation dynamic (original Hogwarts, anyone?)
The moons waxing and waning to give spellcasters more power.
Knights of Solamnia, the first "prestige" class I ever aspired to.
Having to sneak through vast swaths of land occupied by not just random monsters, but a hostile, organized, and evil army.
And is there a cooler name for an evil deity than Takhisis?
Add some new concepts, and viola: just an awesome campaign setting.
I was thinking about this yesterday myself. Why not go with a Dark Sun-style reboot of the original series. Create a campaign setting focused on the early days of the War of the Lance, and let players base themselves in that era. Provide 4E-updated stats for the Companions as example characters, but don't require that those characters exist at all in the world of Krynn 4E.
Since the advent of 4E I've always been an advocate of setting the campaign era in the Age of Mortals, which I think was a pretty cool era in Dragonlance (thanks in large part to Margaret Weis' wonderful Mina-based books- Dragons of Summer Flame, War of Souls trilogy, Dark Disciple trilogy). It doesn't require any further cataclysms either. However, maybe the Dark Sun idea was a good one. It would surely remove the "we're just bit players in the Companions' story" stigma of the setting.
I love the material in Dragonlance. Wizards of High Sorcery, Moon-based magic, the interplay of the pantheon without any god being in complete control. Some would argue that Takhisis was overpowering, but even though she played a prominent position in some cataclysmic wars, even the gods not necessarily in "opposition" to her were still imploring their followers to pursue that god's own ends. Sacrifice plays a major role in the setting as well, even as a mechanic (such as wizardly power at the expense of some form of health-your dump stat MATTERS in Dragonlance).
The only anti-Dragonlance argument I can completely get behind is the anti-kender sentiment. I've been fortunate enough to have never had to deal with the "jerk kender player" but I understand that many have. No one at the table should have reign to be a jerk to co-players. I understand the innocent
intent behind kender, but clearly it doesn't play like that at many tables. That would need to be addressed in a 4E version, even if it means a complete nerf of the race's fluff.