Oathbound: High powered high fantasy, big mashups of things yanked from thousands of fantasy worlds crammed together by divine beings working for a purpose using Raveloft style grabs from other worlds. A great world reason to have things from disparate backgrounds along with a hundred PC humanoid races and a thousand monster adversaries. I particularly like Wildwood the wilderness continent ruled by elves, green dragons, goblins, werewolves, and dogmen with lots of druid/barbarian action as well as Penance the ubercity with bloodlords carving it up and intriguing against each other atop a foundation of a mile high ruin ripe for dungeoneering.
I've heard good things about Golarion and got the big setting book but haven't started reading it yet. I was less than wowed with the 32 page supplement they did for their Egypt knock off country.
Freeport is a lot of fun, pirates, city stuff, nautical crossroads, and mythos cults.
I like a bunch of the Ptolus world, particularly the big theocratic empire with a witch hunting paladin god.
I used to be very big on Ravenloft, horror D&D with no sense evil and limited divinations, I ran it as basically Call of Cthulhu but you are expected to fight the horrors and live.
The Argyle lorebook appeals to me for points of light, it sets up as being 100 years after the fall of a high magic mage empire to a magical plague, so there are reasons for magical dungeons with monsters and loot as well as most people huddling in towns scared of the monsters in the woods while the PCs are the badasses on the block.