Strange that no one has suggested it yet, but I think that Technomancer is one of the more interesting settings. This assumes you want some sort of setting rather than just ideas of how to mix different genres.
The setting is modern world with magic, Missles and Magic. This allows your players to deal with modern (well, actually a few decades ago) situations yet still encounter magic. The history diverges from our history with the first A-bomb test, which makes it a little easier.
Before you go too far with GURPS, I would suggest you try a few mock combats and situations. Get a reasonable handle on the rules before diving heavily into a campaign. This allows you and your players to try a few different character designs before starting the 'real' campaign.
The setting is modern world with magic, Missles and Magic. This allows your players to deal with modern (well, actually a few decades ago) situations yet still encounter magic. The history diverges from our history with the first A-bomb test, which makes it a little easier.
Before you go too far with GURPS, I would suggest you try a few mock combats and situations. Get a reasonable handle on the rules before diving heavily into a campaign. This allows you and your players to try a few different character designs before starting the 'real' campaign.