I'm much more interested in running games; I do apologize if I wasn't specific on that in my OP. I haven't gotten to PLAY in years - I always end up running the games (people like my games, and I'm happy to do the work)... which is why my question is truly about the investment - I'm going to need a gad of books (as Alzrius pointed out) to get all the nuggets I might want/need; I'm familiar with the WotC model of breaking up material into multiple books (TSR pioneered the model, and it works).
Then you should LOVE 4E. One of the great strengths of the game is how much easier it is to run the mechanical side of it so you can have more time for designing the actual world.