Well, if you get proper medical care anyway.
I love the fact that being drunk or high lets you shrug off punishment, because that's what berserkers are. Because people have gotten drunk before going into battle as a survival strategy for millenia. Because it would be funny in actual play.
But I think I'd rather have intoxication give you temporary hp, or allow you to regain 1d6 temporary hp on a successful attack against you. That way you still need healing before you sober up, or you are in big trouble when you do feel the pain.