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There's been a bit of cross-pollination with MTG and D&D over the past couple years, with Ravnica, Theros, and Strixhaven getting D&D books launched a little after their card releases. The newest MTG release is New Capenna, where fiends of various types have formed crime families in the once-angel ruled city of New Capenna. Heavily inspired by the 1920s gangs of New York and Chicago, this setting has a very specific genre in mind.
Now, is it likely that this setting serves as the setting for an upcoming book in 2022? My guess is likely "no" based on what we already know... but WotC loves to surprise us!
That said, this setting could prove good ground for a few new races (like rhinofolk?) and even some more urban-inspired subclasses. Feel free to discuss below your thoughts on New Capenna, and whether it has a future in D&D.