Don't know if this is the type of thing you're looking for at all, or not. But here goes.
In
this setting I run a
Byzantine Roman/Greek/Mixed Group. On occasion I also run an
African and an
Asian/Asia Minor Group. This setting is semi-historical. It is our world circa 800 AD, and consists of humans and animals only. Although on occasion it gets invaded by monsters from outside our world or by creatures from outside our world. It is not a Western European setting or game, as I suspect you might mean by saying vaguely European. Though it does have some Western European characters who are immigrants from the West.
This setting is nothing like Europe or the West as the world is completely devoid of all humans except on one little sanctuary island (where there are less than 300 humans and they are mostly sterile) that they call the Isle of Wight. Otherwise it's all Elves, Dwarves, Giants, and monsters and their cultures are not like human cultures and their magic is nothing like human magic (as a matter of fact humans don't have magic). This world is mythological and high fantasy. It has a
non-human team.
This setting, which I'm just constructing is all islands (except at the poles) and will have vastly different types of cultures, governments, religions, supernatural forces, and even different types of magic. This world will be more like pulp fantasy. There won't be any cultures like Western Europe though. Not really. the players won't start out with new characters, but with characters from the other worlds, but their abilities and classes will be different.
These three worlds are separate, but interrelated, and you can get from one world to another, but it is difficult to do so. The first two worlds are identical geographically, but totally different in population groups, languages, cultures, etc. and as regards plant and animal and insect life. They also have somewhat different geologies.
The last world is all islands, and contains humans, elves, dwarves, giants, monsters, etc. It has a mixture of monsters, plant life and animal life from our world and from the second world.
Don't know how or if that will help you, maybe it will give you some ideas.
I don't really know though if you're looking to start a whole new setting or world, trim away some of what you have, change it around, add onto it, or break it into separate pieces. I guess you need to decide what approach you're gonna or wanna take in that respect. Before you can decide how you wanna proceed.