EricNoah said:
Save or Die doesn't usually make for a very fun game, in my experience. Players should be allowed to use their characters' skills/abilities to survive, or their own cleverness. Pure random luck determining such a big/important thing is no more fun that playing a slot machine.
I agree. To combat this in my campaign, I've done two things:
1) No Greater Spell Focus, etc., to raise save DCs to ridiculous levels.
2) Rocks O' Fate!
Basically, each player got two nifty little colored stones at the beginning of each *session*. One is a personal ROF, one goes in a party pool.
During the session, any player may spend a ROF to reroll any roll, or make an enemy reroll any attack roll. (No fair trying to make them reroll saves!) The reroll is at +2/-2 (the player's choice). A player must use his personal stone first, then take one from the pool; max of two stones per roll. Yes, it's like you're own personal Luck Domain, but better.
And that's pretty much that. When a PC absolutely
needs to do something cool or dramatic . . . he can. Probably

. Additionally, he's probably not going to die to the first Save or Die spell thrown at him.
On the other hand, neither will the Big Bad. Random mooks don't get ROFs, but the Big Bad's 2nd in command will probably have one, and the Big Bad himself will have at least two or three. So the climactic battle against the party is simply not going to end in one round . . . not because of save-or-die or a lucky crit with a heavy pick, at least.
(The other nice thing is that I can be less concerned about killing off the entire party by accident. Encounters tended to be rather nasty on average, and the ROFs are a nice buffer.)
Try it, you'll like it . . .