We seem to be OK with normal humans who do things that are as farfetched as jumping over buildings - surviving wounds and attacks that no normal human would survive, healing damage faster than even the most cutting-edge medical science can achieve, recovering from acid and concussions and poison with no lasting effects. I don't understand the argument that we can handwave those things, but "a female PC can be as strong as a male PC" is less like those things and more like jumping over a building.I'm with Alzrius on this. I most enjoy games when they are as realistic as possible, where the fantasy elements are limited to what the game is about. As a simplistic example, D&D is about fighting monsters with magic and swords, so I expect fantastic monsters and magic, but not normal humans with the ability to jump over buildings.
So men being stronger than women in-game sounds just fine to me, unless a main theme of my game is "What if women were as strong as men?" Though if a player came to me and said "I want to play a woman fighter who's as strong as a man" that would be just fine too, as that's obviously a theme that player wants to address in the game.