Particulars of the game? 3-4 hours on Friday nights. Say 7-11 as the normal game time. I would hope it would be on the weeks we are not playing Vince's game on Saturday.
The easiest style of game for me would be one where I can use one of my pre-existing superhero worlds. I would be leaning toward San Angelo or Freedom City, mainly because both of those are available for Mutants and Masterminds (although San Angelo is not M&M Second Edition, so it would require some tweaking on my part.) I would also like to run M&M because it is an extremely simple system to use in that it uses only one type of die roll to resolve everything (d20s) And, as far as I know, it is the only superhero game system that is being actively supported right now, so rules and such would be readily available.
The benefits to going that route is that there is a wealth of background material, villains and criminal organizations already in place that I could draw from. I would only have to come up with overall plots and subplots involving the PCs. I could start running a game like that this week, if we wanted. (Although I am expecting us not to start for a few weeks, I'm just saying we COULD.)
If you guys didn't want to go that route, we could use any game system, since I would be making everything up from scratch (such as Vince's thoughts way back when that he wanted to play in a game world where the PCs are the only superheroes.) This would obviously be more time consuming and require more prep time, but we could use any of my superhero rules for that game.
In either case, we could set the game in the Golden Age or the modern era, or even both, using characters that are somehow related over the years to move back in forth in time depending on the given session's plotline.
One thing I would like to see is some way for all the characters to be tied together, so I can involve more people in the plotlines and subplots. Think Fantastic Four, where everyone is related or good friends living in the same house, or X-men where everyone is a mutant, a student and lives in the same school. I've got several ideas along those lines that I will throw out later today. Although having completely individual characters works well in the comics where one hero frequently has an entire comic book to himself, that doesn't work well in superhero games because while Flash's character is off in Central City dealing with his issues the other players are growing bored.