Like most genres in RPGs, either the players are actually on board with the genre and its conventions, or the game will fail. Playing horror where the PCs simply nope out and run away...game's over. Unless the horror follows them home for some reason. Playing superheroes where the PCs simply ignore civilian casualties and murder all the villains...game's over. Unless you're specifically going for the Snyder-Verse. But then, that's not superheroes. That's action movies with superpowers. Entirely different genre.