I have played in campaigns that are vile enough to make the BOVD run off with its tail (pointed natch) between its proverbial legs
Slavery, Murder, Sexism, Torture you name it we have had it it in game
Heck we have had Boy Brothels (not when I ran though eeew) Torture of Children (only once, the players crossed the invisible line and that campaign died) Sex Slaves (when I was young

) and worse
I can't say I enjoy that sort of thing in games so, while its not realitic I sanitized most of it out along with Graphic Sex and Ultra Violence
Its a bit PC, sure but its more fun for me. I want adventure not Realism...
As far as buying a setting with some of those elements?
Sure.
Heck I plan on picking up Perils of Gor
I can rule Zero what I don't like and the Gor supplement will likley some raidable bits
In the game I was last playing in, Pyrates of Glorianas Second Reign (or something) we had Nationalism, Sexism, Racism and a shocking amount of Anti Catholic bigotry.
Heck our partys Assassin/Rogue/Twin Rapier Twink Ranger had species enemy "Catholics" which was alllowed on anyone who displayed any Catholic traits.
This bothered me mainly because they players had a touch of that attitude IRL, that was the problem not the roleplaying
it wasn't enough to spoil the game as long as it was kept in character only. The real bigotry OTOH
The campaign died of other causes. I say good riddance.
On the whole the various real world uglies really aren't much worse than the fact that many D&D partys are an unwholesome combo of Grave Robber and Home Invasion Robber
Not all of them, heck not most of them.
Still there are plenty of "They are just Orcs Lets Kill em and take their stuff" attitude out there for me to have commented "
Substitute your favorite minority for Orc" and reframe, the thought makes me a little creepy actually
Since we are all adults who can seperate fantasy from reality this isn't a problem howver just to spare my SAN I am not allowing evil characters without forwarning